The major sticking point for modern System Shock players is the control scheme, which uses keys instead of the mouse to look around. An unofficial patch hacked in mouselook several years ago, but the Enhanced Edition includes it by default, plus more optional control schemes, bug fixes, and support for higher resolutions. (The original game is also included.) If you happen to have a VFX-1 headset lying around, I also recently learned that you can play it in glorious '90s virtual reality. Unfortunately, that sounds actually more painful than anything a rogue AI might do to your pathetic human flesh.
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